Tessarz Lab 

Research in our group is aimed towards understanding fundamental questions regarding the regulation of gene expression by chromatin architecture, the impact of cellular metabolism and the (micro)environment on the formation of chromatin states and transcriptional variability. We are particularly intrigued by decision-making processes of cells during differentiation and and would like to understand how the metabolism-epigenetics axis is involved in this process.

 

To address these questions, we use tissue, biopsies, and stem cell models to dissect the connection between metabolism and epigenetics on a mechanistic level, employing biochemical, cell biological, and deep-sequencing approaches, including spatial and single-cell resolution technologies. A long-term goal of our research is to identify pathways within the metabolism-epigenetics axis that can be exploited for interventions to positively impact disease outcome and/or ageing.

​

​A long-term goal of our research is to identify pathways within the metabolism-epigenetics axis that can be exploited for interventions to positively impact disease outcome and/or ageing and to extend human health-span.