Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells
Kroef V., Hund L., Barenco Abbas Y., Tamura N., Fröhlich J., Huber A.-K., Ali S.M., Wischhof L., Scheiblich H., Giavalisco P., Denzel M.S., Tessarz P., Huppertz I.
bioRxiv (2025)

IFN-β Production Promotes Metabolic Rewiring and Protection Against Oxidative Stress in Hepatitis Delta Virus-Infected Hepatocyte Cultures
Khomich O.A., Giavalisco P., Parent R., Krasnov G.S., Tessarz P., Meuleman P., Burm R., Zakirova N.F., Molle J., Batbold E., Gottlieb E., Zoulim F., Ivanov A.V., Bartosch B.
Cell Death & Disease (2025)

Persistent Epigenetic Memory of SARS-CoV-2 mRNA Vaccination in Monocyte-Derived Macrophages
Simonis A., Theobald S.J., Koch A.E., Mummadavarapu R., Mudler J.M., Pouikli A., Göbel U., Acton R., Winter S., Albus A., Holzmann D., Albert M.-C., Hallek M., Walczak H., Ulas T., Koch M., Tessarz P., Hänsel-Hertsch R., Rybniker J.
Molecular Systems Biology (2025)

 

H3K56 Acetylation Affects Candida albicans Morphology and Secreted Soluble Factors Interacting with the Host
Conte M., Eletto D., Pannetta M., Esposito R., Monti M.C., Morretta E., ...
Biochimica et Biophysica Acta (BBA) – Gene Regulatory Mechanisms (2024)
 

Artificial Hsp104-Mediated Systems for Re-Localizing Protein Aggregates
Fischbach A., Johns A., Schneider K.L., Hao X., Tessarz P., Nyström T.
Nature Communications (2023)
 

Spatial and Single-Cell Profiling of the Metabolome, Transcriptome and Epigenome of the Aging Mouse Liver
Nikopoulou C., Kleinenkuhnen N., Parekh S., Sandoval T., Ziegenhain C., Schneider F., Giavalisco P., Donahue K.-F., Vesting A.J., Kirchner M., Bozukova M., Vossen C., Altmüller J., Wunderlich T., Sandberg R., Kondylis V., Tresch A., Tessarz P.
Nature Aging (2023)

 

Dimension Reduction by Spatial Components Analysis Improves Pattern Detection in Multivariate Spatial Data
Kleinenkuhnen N., Köhler D., Baar T., Nikopoulou C., Kondylis V., Schmid M., Tessarz P., Tresch A.
bioRxiv (2023)

Aging Is Associated with Increased Chromatin Accessibility and Reduced Polymerase Pausing in Liver
Bozukova M., Nikopoulou C., Kleinenkuhnen N., Grbavac D., Goetsch K., Tessarz P.
Molecular Systems Biology (2022)

Hypoxia Promotes Osteogenesis by Facilitating Acetyl‐CoA‐Mediated Mitochondrial–Nuclear Communication
Pouikli A., Maleszewska M., Parekh S., Yang M., Nikopoulou C., Bonfiglio J.J., Mylonas C., Sandoval T., Schumacher A.-L., Hinze Y., Matic I., Frezza C., Tessarz P.
The EMBO Journal (2022)

 

RNA-Sequencing of Single Cholangiocyte-Derived Organoids Reveals High Organoid-to-Organoid Variability
Gehling K., Parekh S., Schneider F., Kirchner M., Kondylis V., Nikopoulou C., Tessarz P.
Life Science Alliance (2022)

The Impact of Genomic Variation on Protein Phosphorylation States and Regulatory Networks
Grossbach J., Gillet L., Clément-Ziza M., Schmalohr C.L., Schubert O.T., Schütter M., Mawer J.S.P., Barnes C.A., Bludau I., Weith M., Tessarz P., Graef M., Aebersold R., Beye A.
Molecular Systems Biology (2022)

Histone N-Terminal Acetyltransferase NAA40 Links One-Carbon Metabolism to Chemoresistance
Demetriadou C., Raoukka A., Charidemou E., Mylonas C., Michael C., Parekh S., Koufaris C., Skourides P., Papageorgis P., Tessarz P., Kirmizis A.
Oncogene (2022)

​

Effects of Hst3p Inhibition in Candida albicans: A Genome-Wide H3K56 Acetylation Analysis
Conte M., Eletto D., Pannetta M., Petrone A.M., Monti M.C., Cassiano C., Giurato G., Rizzo F., Tessarz P., Petrella A., Tosco A., Porta A.
Frontiers in Cellular and Infection Microbiology (2022)​

 

Molecular Role of Lipids in Aging
Skowronska-Krawczyk D., Narayan P., Tessarz P.
Frontiers in Aging (2022)

​

Epigenetic Alterations in Stem Cell Ageing — A Promising Target for Age-Reversing Interventions?
Pouikli A., Tessarz P.
Briefings in Functional Genomics (2022)

​

Nhp2 Is a Reader of H2AQ105me and Part of a Network Integrating Metabolism with rRNA Synthesis
Mawer J.S.P., Massen J., Reichert C., Grabenhorst N., Mylonas C., Tessarz P.
EMBO Reports (2021)

​

Chromatin Remodeling Due to Degradation of Citrate Carrier Impairs Osteogenesis of Aged Mesenchymal Stem Cells
Pouikli A., Parekh S., Maleszewska M., Nikopoulou C., Baghdadi M., Tripodi I., Folz-Donahue K., Hinze Y., Mesaros A., Hoey D., Giavalisco P., Dowell R., Partridge L., Tessarz P.
Nature Aging (2021)

​

Long-Lived Macrophage Reprogramming Drives Spike Protein-Mediated Inflammasome Activation in COVID-19
Theobald S.J., Simonis A., Georgomanolis T., Kreer C., Zehner M., Eisfeld H.S., Albert M.-C., Chhen J., Motameny S., Erger F., Fischer J., Malin J.J., Gräb J., Winter S., Pouikli A., David F., Böll B., Koehler P., Vanshylla K., Gruell H., Suárez I., Hallek M., Fätkenheuer G., Jung N., Cornely O.A., Lehmann C., Tessarz P., Altmüller J., Nürnberg P., Kashkar H., Klein F., Koch M., Rybniker J.
EMBO Molecular Medicine (2021)

​

The RNA-Binding Protein Puf5 Contributes to Buffering of mRNA upon Chromatin-Mediated Changes in Nascent Transcription
Kochan D.Z., Mawer J.S.P., Massen J., Tishinov K., Parekh S., Graef M., Tessarz P.
Journal of Cell Science (2021)

​

N1-Acetylspermidine Is a Determinant of Hair Follicle Stem Cell Fate
Allmeroth K., Kim C.S., Annibal A., Pouikli A., Koester J., Derisbourg M.J., Chacón-Martínez C.A., Latza C., Antebi A., Tessarz P., Wickström S.A., Denzel M.S.
Journal of Cell Science (2021)

​

Metabolism and Chromatin: A Dynamic Duo that Regulates Development and Ageing — Elucidating the Metabolism–Chromatin Axis in Bone-Marrow Mesenchymal Stem Cell Fate Decisions
Pouikli A., Tessarz P.
BioEssays (2021)

​

NET-Prism Enables RNA Polymerase-Dedicated Transcriptional Interrogation at Nucleotide Resolution
Mylonas C., Tessarz P.
RNA Biology (2019)

​

Ageing and Sources of Transcriptional Heterogeneity
Nikopoulou C., Parekh S., Tessarz P.
Biological Chemistry (2019)

​

SIRT7-Dependent Deacetylation of Fibrillarin Controls Histone H2A Methylation and rRNA Synthesis during the Cell Cycle
Iyer-Bierhoff A., Krogh N., Tessarz P., Ruppert T., Nielsen H., Grummt I.
Cell Reports (2018)

​

Transcriptional Repression by FACT Is Linked to Regulation of Chromatin Accessibility at the Promoter of ES Cells
Mylonas C., Tessarz P.
Life Science Alliance (2018)

​

Histone Modifications in Ageing and Lifespan Regulation
Maleszewska M., Mawer J.S.P., Tessarz P.
Current Molecular Biology Reports (2016)

Histone Core Modifications Regulating Nucleosome Structure and Dynamics
Tessarz P., Kouzarides T.
Nature Reviews Molecular Cell Biology (2014)

​

Glutamine Methylation in Histone H2A Is an RNA-Polymerase-I-Dedicated Modification
Peter Tessarz, Helena Santos-Rosa, Sam C Robson, Kathrine B Sylvestersen, Christopher J Nelson, Michael L Nielsen, Tony Kouzarides
Nature (2014)

​

Cooperative and Independent Activities of Sgt2 and Get5 in the Targeting of Tail-Anchored Proteins
Kohl C., Tessarz P., von der Malsburg K., Zahn R., Bukau B., Mogk A.
Biological Chemistry (2011)

​

The Yeast AAA+ Chaperone Hsp104 Is Part of a Network That Links the Actin Cytoskeleton with the Inheritance of Damaged Proteins
Tessarz P., Schwarz M., Mogk A., Bukau B.
Molecular and Cellular Biology (2009)

​

Substrate Threading through the Central Pore of the Hsp104 Chaperone as a Common Mechanism for Protein Disaggregation and Prion Propagation
Tessarz P., Mogk A., Bukau B.
Molecular Microbiology (2008)

​

Common and Specific Mechanisms of AAA+ Proteins Involved in Protein Quality Control
Mogk A., Haslberger T., Tessarz P., Bukau B.
Biochemical Society Transactions (2008)

​

Novel Insights into the Mechanism of Chaperone-Assisted Protein Disaggregation
Weibezahn J., Schlieker C., Tessarz P., Mogk A., Bukau B.
Biological Chemistry (2005)

​

Thermotolerance Requires Refolding of Aggregated Proteins by Substrate Translocation through the Central Pore of ClpB
Weibezahn J., Tessarz P., Schlieker C., Zahn R., Maglica Z., Lee S., Zentgraf H., Weber-Ban E.U., Dougan D.A., Tsai F.T.F., Mogk A., Bukau B.
Cell (2004)

​

Substrate Recognition by the AAA+ Chaperone ClpB
Schlieker C., Weibezahn J., Patzelt H., Tessarz P., Strub C., Zeth K., Erbse A., Schneider-Mergener J., Chin J.W., Schultz P.G., Bukau B., Mogk A.
Nature Structural & Molecular Biology (2004)

​

Inhibition of Ubiquitin/Proteasome-Dependent Proteolysis in Saccharomyces cerevisiae by a Gly-Ala Repeat
Heessen S., Dantuma N.P., Tessarz P., Jellne M., Masucci M.G.
FEBS Letters (2003)